Neutron Scattering Unravels the Structure of Aromatic "pi-pi" Interactions

 Aromatic interactions arise from delocalised π-electrons, and they play a key role in a very wide range of natural and industrial processes. For example protein folding, DNA and RNA base stacking, protein-nucleic acid recognition, drug design and oil recovery. However, detailed knowledge of the structures adopted by simple model aromatic molecules is currently lacking, and is essential to our fundamental understanding of π-π interactions.

Researchers from the London Centre for Nanotechnology and the ISIS Neutron Scattering Facility (STFC Rutherford Appleton Laboratory) have now obtained definitive structural data for two archetypical aromatic liquids: benzene and toluene. By judiciously labelling these molecules with different isotopes of hydrogen, they were able to use neutron scattering to unravel the spatial and orientational packing of these molecules. The results identify a configuration that is now termed “Y-shaped” as a dominant motif in aromatic liquids. The near absence of the “T-shaped” geometry, previously proposed as the most favourable, is likely to lead to a significant re-evaluation of aromatic interactions in liquids.
The experiments were conducted on the SANDALS instrument at ISIS, and the work was sponsored in part by the Natural Environment Research Council UK (NERC).

The work was featured on the cover of the Journal of the American Chemical Society (T. F. Headen, C. A. Howard, N. T. Skipper, M. A. Wilkinson, D. T. Bowron, A. K. Soper, J. Am. Chem Soc. (2010), 132, 5735–5742. DOI: 10.1021/ja909084e). Contact author Neal Skipper:

Figure 1: A schematic detailing the difference between T-shaped and Y-shaped arrangement of the molecules in liquid benzene

Attached image
Update this image alt text please