My overall research aim is to study the contribution of nanoscale architecture and chemical composition to the structure, function and mechanical properties of collagenous tissues in both health and disease.
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Genetic variation and mechanical properties of collagen at the single molecule level.
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Fibrillar collagen: nanoscale architecture responsible for mechanical stability.
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Impact of the hydroxy-apatite on the Mechanical stability at the nanoscale.
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Development of new-materials for increasing biomechanical stability.
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Development of new scanning probe microscopic tools for biophysics and materials science.
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Interfacing Atomic Force Microscopy and vibrational spectroscopy.
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Thermal physics at the nanoscale.
Micron-scale entanglement of two collagen fibrils 
Resorption lacunae (Dentine) imaged by atomic force microscopy 
Topographical images (height; tapping mode in air) of type I collagen monomers on mica substrate:
a) low surface coverage – 1mg/ml solution,
b) high surface coverage – 10 mg/ml
Recent Papers
Search the UCL Publications Database
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L. Bozec, G. van der Heijden and M. A. Horton, “Collagen fibrils: nanoscale ropes”, Biophys J. (2007) Jan 1:92(1):70-5.
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L. M. Picco, L. Bozec, A. Ulcinas, D. J. Engledew, M. Antognozzi, M. A. Horton and M. J. Miles, “Breaking the speed limit with AFM”, Nanoletters (2007) 18, pp044030
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M. P.E. Wenger, L. Bozec, M. A. Horton, and P. Mesquida, “Mechanical properties of collagen fibrils”, Biophys J. (2007) –15:93(4):1255-63.
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L. Bozec, M.A. Horton, “Skeletal tissues as nanomaterials”, Mater. Sci. Mater. Med. (2006) 17(11):1043-8
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L. Bozec and M.A. Horton, “Topography and Mechanical Properties of Single Molecules of Type I collagen Using Atomic Force Microscopy”, Biophys J., 88 (6), (2005) 4223.
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