Over the past few decades, there has been steady progress in both our ability to produce biological material and in our ability to manipulate matter at small length scales. These two developments merge in a fascinating area of confluence called single-molecule biophysics in which an understanding of biological matter from physical principles becomes possible. In this seminar the developments of this interdisciplinary field will be discussed, as will how several newly developed single-molecule force and torque spectroscopy techniques allow us to shed light on genomic processes such as transcription, replication, and DNA compaction. Lastly, as the true environment of biological molecules is the living cell, a demonstration of our ability to track replication inside bacterial cells and the corresponding future implications will be discussed.
Location: 102 Malet Place, Engineering Building