The LCN is jointly owned and run by UCL and Imperial College London. It has two co-directors, one from each university, responsible for the day-to-day running of the institution as a whole. The LCN co-directors work with an Executive Committee, with input from an external Advisory Board that meets approximately annually.

At UCL the LCN forms an independent research department jointly between the Faculty of Mathematical and Physical Sciences, the Faculty of Engineering and, the Faculty of Life Sciences and the Faculty of Medicine.  At Imperial College it forms a centre with its own space and identified facilities, its members drawn from several related departments.

Ethical issues associated with the technology are addressed through the various LCN boards and networks; the LCN welcomes both debate and education.

In pulling together world-class research, infrastructure and commercial best practices, the LCN ranks with leading nanotechnology facilities worldwide.