Sanjiv Sharma [1]

User Profile

Profile

Dr Sanjiv Sharma

Telephone Number:

020 7594 1843

Telephone Extension:

41 843

Email:

sanjiv.sharma@imperial.ac.uk [2]

Office/Location:

Chemistry

Research Interests:

Microfluidics & Desk top fabrication

Biography

Biography:

Sanjiv Sharma is currently a Research Officer in the Institute of Biomedical Engineering at Imperial College London, a member of the Royal Society of Chemistry and a Chevening Technology Fellow.
He graduated in Biology and Chemistry in 1993 followed by a Masters in Chemistry in 1995 from Dr. Hari Singh Gour University, Sagar (M.P), India. He did his PhD in Chemistry from Regional Research Laboratory (Council of Scientific and Industrial Research), Bhopal, India. Following his PhD research he took up research positions in France (Institut de Physique Nucléaire d' Orsay and Hospital St. Antoine, Paris) and Germany (Walter Schottky Institut, Technische Universitatet Muenchen). He was awarded a Chevening Technology fellowship by the UK Government to work in Imperial College, London (U.K) and do a course on technology commercialization with London Business School (LBS) and Cambridge University.

His main research areas are micro and submicron fluidic systems, non invasive & label free detection systems and proteomics based clinical diagnostic applications. He has published in various internationally peer reviewed journals and filed patent applications in Germany and US. He is presently working in the group of Professor Tony Cass on bionanotechnology and biosensors.

Recent Publications:

Salehi-Reyhani A, Sharma S, Burgin E, et al. [3], 2013, Scaling Advantages and Constraints in Miniaturized Capture Assays for Single Cell Protein Analysis, Lab on a Chip, Vol:13, ISSN:1473-0197, Pages:2066-2074 DOI [4] Publisher Web Link [5]

Moreira FTC, Sharma S, Dutra RAF, et al. [3], 2013, Smart Plastic Antibody Material (SPAM) tailored on disposable screen printed electrodes for protein recognition: application to Myoglobin detection, Biosensors and Bioelectronics, Vol:45, 0956-5663, Pages:237-244 DOI [6] Publisher Web Link [7]

Sharma S, Reyhani AS, Bahrami A, et al. [3], 2012, A novel method for fabricating nanostructures via nanotemplates using dip pen nanolithography, Micro & Nano Letters, Vol:7, 1750-0443, Pages:1038-1040 DOI [8] Publisher Web Link [9]

Radomska-Botelho Moniz A, Michelakis K, Trzebinski J, et al. [3], 2012, Minimally Invasive Enzyme Microprobes: An Alternative Approach for Continuous Glucose Monitoring, Journal of Diabetes Science and Technology, Vol:6, Pages:479-480 Publisher Web Link [10]

Awards and honours:

Chevening Technology Award, Foreign and Commonwealth Office, 2004

Chartered Chemist (CChem), Royal Society of Chemistry, 2006

Chartered Scientist, Royal Society of Chemistry, 2006

Home research group: Cass Research Group, Biosensors and Bionanotechnology [11]

Research

Research:

Research in the group falls broadly into the area of bioanalysis with a particular focus in the following areas:

Biosensors: We are producing sensors based on both optical and electrochemical signal transduction schemes for applications in personal healthcare, bioreactor monitoring and clinical diagnostics. These biosensors often exploit engineered proteins.

Protein Engineering: Although proteins have been widely used in bioanalysis many of their properties are not optimally suited to this application. We are therefore using protein design tools to re-engineer the properties of proteins to better suit them to this application.

Microarrays and Microfluidics: Microarrays offer the possibility of massively parallel analysis. We are working on arrays where the content is based on non-antibody binding proteins of either narrow or broad specificity. We are also exploring the use of pattern recognition methods to relate array signatures to the state of the system under analysis.

Proteomics: We are using both 'conventional' as well as nanomaterials based proteomics to understand how the changes occurring in the protein complements of biological systems relate to their behaviour. In particular, we are interested in the proteomic profiles that develop during the growth of stem cells in controlled culture and during the interactions of cells with synthetic materials.

Research Highlights:

Publications

News