Yaron Silberberg

Mechanobiology; Mechanotransduction in single cells
Mitochondrial transport; Cytoskeleton morphology
Atomic Force Microscopy, Fluorescence and
Laser Scanning Confocal Microscopy

Contact details:
Office: 5P2Q
Tel: +44 (0)20 7679 7701
Ext: 22222
Fax: +44 (0)20 7679 0595
Email: y.silberberg

ucl.ac.uk

Research Interests and Biography
Yaron Silberberg obtained his B.Sc. in Biotechnology in 2005 at University College London. He is currently doing his Ph.D. at the London Centre for Nanotechnology and the Centre for Nanomedicine, at University College London. His research focuses mainly on the influence of nanomechanical stress on the cell’s interior morphology and behaviour.

Recent Publications

Silberberg, Y.R., Pelling, A.E., Crum, W.R., Hawkes, D J. and Horton, M A. Mitochondrial Displacements in Response to Nanomechanical Forces J. Molecular Recognit. 21:30-36 (2007). [PDF file]

Pelling, A.E., Nicholls, B.M., Silberberg, Y.R., Horton, M.A. Approaches for Investigating Mechanobiological Dynamics in Living Cells with Fluorescence and Atomic Force Microscopies, in Méndez-Vilas, A. and Díaz, J. Eds. Modern Research and Educational Topics on Microscopy. Formatex, pg. 3-10, (2007). [PDF file]

Silberberg, Y.R., Pelling, A.E., Yakubov, G.E., Crum, W.R., Hawkes, D.J. & Horton, M.A. Tracking displacements of intracellular organelles in response to nanomechanical forces. 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro. ISBI 2008. [PDF file]

Research

A NIH-3T3 Skin Fibroblast cell under the tip of an Atomic Force Microscope (AFM). The use of AFM allows precise and well-defined perturbations to be applied on the living cell. In combination with optical and fluorescent techniques, we can follow the effect of the perturbations on intracellular organelle displacements. Scale bar: 20μm.		Fluorescent image of NIH-3T3 cells. The cells are stained with organelle-specific dyes: Nucleus - Blue; Actin filaments - Green; Mitochondria - Red. Using AFM in combination with fluorescent microscopy, it is possible to follow the real-time interactions between different organelles (e.g. Mitochondria-Actin filaments) in live cells.